Harmonizing Spatial Biology and Immunophenotyping to Characterize the Tumor Microenvironment

January 31, 2023 | 11:00AM EST | USA

Multiplex immunofluorescence (mIF) assays offer the advantage of preserving the architectural features of the tumor microenvironment (TME) and revealing the spatial relationships between tumor cells and immune cells that are present. Using an Ultivue 8-plex mIF assay enabled the team to elucidate the T cell phenotypes spatially and quantitively in the context of Adaptimmune’s engineered SPEAR-T cell therapy infiltration within the TME. In this GEN Webinar, our distinguished presenters, Dr. Robyn Broad and Dr. Martin Isabelle will show us examples of patient baseline and post-infusion biopsies for multiple indications to demonstrate how they use these analyses to quantify cell densities of subsets of infiltrating immune cells and observe cellular spatial patterns within the tumors.

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