A complete supplement is an important part of the biopharmaceutical manufacturing process.
Injection needles molds made from polyurethane ether ketone (PEEK) or stainless steel are advanced in manufacturing and are proving valid in many applications containing injectable drugs in water, biology, and vaccines. This change is not the only advantage. As part of the removable disc line or gamma irradiation, the injection is a simple procedure. However, the polymeric material eliminates the cost and time associated with the cleaning stand and is therefore attractive in stainless steel.
A vial can be damaged by needle injection which greatly reduces the flexibility of the polymeric material it contains. However, challenges, such as injections into the biopharmaceutical replacement system, are reducing the needle’s ability to jam or shrink and costly downtime that could cause damage to many of the supplement control systems.
So why is the needle full of needles or is sticking out and how can we effectively reduce this effect? These questions can be answered if we take a closer look at the needle type, needle size, and physical characteristics of the final procedure.
How the inner diameter affects the final fill performance
Fill the required volume with a strong consistency that will make the first decision on the choice of needle size. The internal diameter of the needle will affect the starting and starting dose of the dose. The size of the needle must be determined considering the characteristics of the fluid and the required filling speed. It is also important to consider the inside diameter of the bag to eliminate waste and allow enough air to escape when the bag is filled with water. A small needle can also be used to reduce the filling rate to maintain the integrity of the filling and avoid water drainage.
Analysis of needle size and processing viscosity
Blockages are usually found at the end of the long segment or after the end of the seal, due to fluid leaking, on or near the top of the needle. This results in a complete or partial blockage of the needle. With a small needle, the needle can be threaded close to the needle tip, especially if the process is stopped or if a longer retention period is required during filling.
It can be said that water repellency is water repellent: liquids seal quickly in front of the detergent which can stretch quickly, barely or barely. High-density dry needles (polymers, proteins, mAbs, etc.) are commonly found. Pushing such a viscous solution through a small diameter pouch with a small needle can lead to hair loss and other factors. the effects can also interfere with the processes of protein derivatives.
Experiments show that it takes longer to insert a large needle than a small needle. The fact is that when increasing the size of the needle, it is necessary to consider the volume and viscosity of the system.
Factors contributing to the reduction of water losses and blockages: optimization of fishing rods and wettability of the material.
Improvements to the pump have been found to improve the flow rate into the needle lumen as it affects the drying rate of the system. Without optimization, this “water extraction” during operation can cause overcrowding and overcrowding, product loss, and longevity. One way to reduce this is to reduce the viscosity density of the pharmaceutical product by carefully selecting the ingredients. The large batch processing capacity is well demonstrated in optimal fish management.
Needle inserts have also been shown to be the most time-consuming process for cleaning and injection of needles, due to the relationship between liquid material and needle material. The needle is made of a hydrophobic material that allows liquid to drain from the top of the needle, reducing the drying rate of the system. Even if there isn’t enough water (i.e., leaving a drop at the top of the needle), there may be too much dryness in the hydrophobic needle tip, preventing clogging.
The effect of water velocity resulting in leakage
The incompatible high-frequency profile will affect the initial accuracy when filling. However, our experiments show a correlation between liquid rate and liquid processing. It floats slowly, as it carries a high risk of puddles and large drops. It is also true that the droplet size will reduce the amount of soil close to the needle, while the deep layer rate is maintained. Therefore, it can be assumed that the surface area thickness will decrease by reducing the maximum hole strength. This will allow the velocity of the water to increase in this area and thus reduce the chances of absorption.
This practice makes high concentration / high viscosity processes
For example, monoclonal antibodies (mAb) are usually given as an intravenous injection, but subcutaneous injection is the best option, especially for patients with chronic diseases who require repeated administration of mAb throughout life. Developing a mAb system for subcutaneous control of size and viscosity is critical. . Since underground cavities do not know what to deliver, mAb formulations are usually formulated as solid solutions, usually in the hundreds of mg/mL, resulting in high viscosities. In addition, salt, sugar, and other impurities can increase the viscosity of the final process.
Blood viscosity increases significantly with increasing. High protein concentrations may have viscosity levels that pose unique challenges for liver transplantation and drug completion. The selection of tubes having different maximum strength Shore, inside/outside diameter, and final configuration play an important role in managing the effect of viscosity.
Need for needle construction
Precise alignment and stitching can provide stability by controlling lumen diameter, wall thickness, smoothness, and sharpness of the hole. Fill the needle usually into the bag and begin to fill the bottom of the bag, slowly rising to the end of the dosing process. Therefore, the length of the needle during this operation is important to avoid contact with the bag. The needles are made entirely of stainless steel, but in recent years, it has been shown that solid plastics such as polyurethane baskets (PEEK) are the same, if not more accurate and consistent, and uniform.
In summary, when comparing injection filling operations with winners, end-users should consider the following in their pharmaceutical products: good filling, tendency to drain, tendency to clean the drug product at the needle tip, and how long you take to meet the required goals. first.
Our goal is to provide various filling diameters based on GMP-defined materials, designed to reduce interference during the final processing process. Our Allegro meeting needles meet these criteria and are disposable and ready to use, something that will be needed to enter the team system.